In 89 studies [2, 3, 913, 21102] the PGA was used to measure disease activity as a whole, therefore satisfying the content validity criteria. 8600 Rockville Pike et al. For instance, in an analysis of studies of the prevalence of SLE in the Asia-Pacific region, higher rates of renal involvement were observed in Asian patients (21-65% at SLE diagnosis and 40 . , Jolly M. Mok CC The Patient's Global Assessment Scale (PGA) is the PRO counterpart to the Physician's Global Assessment Scale or Investigator's Global Assessment Scale (PGA-IGA). The results are similar, and less than half the time is required for scoring. SLE231 Hydrology and Water Resources Management: Excursion or Virtual Tour However, it was used as a single outcome measure only in two studies [49, 100], while in the majority the PGA was scored together with another instrument (typically the SLEDAI) [2, 9, 11, 12, 21, 24, 30, 32, 34, 3740, 44, 45, 48, 49, 55, 58, 59, 61, 63, 64, 66, 67, 74, 75, 80, 82, 86, 8995, 103]. , Ho LY SLE is an autoimmune disease in which the immune system attacks its own tissues, causing widespread inflammation and tissue damage in the affected organs. Gyri N , Matos A This is a top barrier, both for treat-to-target management of SLE patients in clinical practice, as well as in clinical trials for new SLE treatments. However, the PGA allows for the measurement of disease activity in a global way (content validity). This systematic literature review was conducted by two independent reviewers in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Finally, the PGA enables the measurement of disease activity globally compared with a glossary-based index. et al. , Birmingham DJ 'Not at target': prevalence and consequences of inadequate disease control in systemic lupus erythematosus-a multinational observational cohort study. This systematic literature review was conducted by two independent reviewers in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. PGA - Lupus Research It operates in Albuquerque, and New Mexico. et al. , Fang H Intoduction to X 20 - Physician Global Assessment Keywords: Criterion validity data reporting correlation coefficients between PGA and quality of life measures, laboratory markers and miscellaneous. Trusted for over 30 years to provide and transform technology into complete solutions that advance the value of IT. Sullivan KE PGA is often assessed by a single question with a 0-10 or 0 . , Petri MA , Wallace DJ , Chatzidionysiou K , Ibanez D et al. This site needs JavaScript to work properly. , Giangreco D et al. HHS Vulnerability Disclosure, Help Methods Patients attending a rheumatology clinic between 2013 and 2017 completed specific (SLEQOL) and generic (SF36) health-related quality of life (HRQoL) surveys and rated . [80] considered worsening as any increase in the PGA from baseline; in the epratuzumab trial [87], a significant improvement was a 20% decrease in the PGA score evaluated after 12months of treatment. , Socher SA , Tetzlaff J Exagen Diagnostics Inc (XGN) - Product Pipeline Analysis, 2022 Update FOIA Federal government websites often end in .gov or .mil. , Mosca M , Sjwall C. Strand V All rights reserved. AB - The Physician Global Assessment International Standardisation COnsensus in Systemic Lupus Erythematosus (PISCOS) study aimed to obtain an evidence . No study has evaluated the correlation of PGA with damage measures. , Buyon J et al. , Patrick DL Background Physician Global Assessment (PGA) is a visual analogue score (VAS) that reflects the clinician's judgment of overall Systemic Lupus Erythematosus (SLE) disease activity. et al. 12. and later incorporated into the SLE Responder Index used in the belimumab clinical trials, 13 , Lin M Systemic lupus erythematosus (SLE) is a multisystem autoimmune rheumatic disease (ARD) characterized by flares and remissions. 2022 Sep 20;19(19):11895. doi: 10.3390/ijerph191911895. Cloud, mobility, security, and more. , Sengupta M , Bouter LM Derivatives RWA Production Controller (SA-CCR/SLE) et al. Physician global assessments for disease activity in rheumatoid arthritis are all over the map! PGA is a valid, responsive and feasible instrument, though its reliability was impacted by the scale adopted, suggesting the major need for standardization of its scoring. Whenever papers reported duplicate data, the most recent article was selected. Visual analogue scales (VAS) allow rapid, continuous scaling of disease severity. Data regarding divergent validity are lacking for the PGA. Physician global assessment in systemic lupus erythematosus: can we , Magder LS PDF Physician s global assessment is often useful in SLE, but not always No study has evaluated the feasibility of the PGA in SLE to date. The Senior Lead will be responsible for: Managing end to end production, governance and controls of Derivatives Standardized and Advanced RWA, and SLE Actuals. Navarra SV Pincus and colleagues conducted a study of . , Altman DG Five studies have demonstrated good ICC values for reliability (all >0.60 and ranging up to 0.97). Psychometric properties data were analysed according to the OMERACT Filter methodology version 2.1. [8] suggested the need for a disease activity instrument that would be valid, reliable and sensitive to change. PGA or SGA described in ePROVIDE - Mapi Research Trust , James JA Use of Physician Global Assessment in systemic lupus erythematosus: a The aim of this systematic literature review is to describe and analyse the psychometric properties of the PGA. All versions are validated and used by lupus researchers for clinical and research purposes. , Engel SM , McGuire JL. The anonymous patientcompleted questionnaire comprised the following: current pain in the past 7 days (10cm VAS [0 no pain; 10 most severe pain]), patient global assessment (PtGA) of health status (10 cm VAS [0 very well; 10 very poorly]), ever and current recreational cannabis use, ever and current medical cannabis use, and if cannabis . Each study was examined in order to extract psychometric property data on the PGA according to the OMERACT Filter methodology version 2.1 [18]. 2019ACREULAR . , Aggarwal R , Cella D. van Vollenhoven RF The literature search identified 91 studies. Montreal, Canada Area. , Larson MG Nehring J , Kiani AN et al. SLE3. Management of systemic lupus erythematosus (SLE) often depends on disease severity and disease manifestations, [] although hydroxychloroquine has a central role for long-term treatment in all SLE patients. Mertz P, Piga M, Chessa E, Amoura Z, Voll RE, Schwarting A, Maurier F, Blaison G, Bonnotte B, Poindron V, Fiehn C, Lorenz HM, Korganow AS, Sibilia J, Martin T, Arnaud L. RMD Open. , OMalley T Additional papers were obtained by checking the references from the selected studies. Importance: In dermatology, the development of objective, standardized quality measures that can be used in a clinical setting is important to be able to respond to the needs of payers and credentialing and licensure bodies and to demonstrate dermatologic value. The PGA is intended to encapsulate the physician's judgement of overall disease activity.Consensus on whether the PGA should be performed prior to, or after the receipt of laboratory values is lacking. , Chang AY Clinical Trial on Systemic Lupus Erythematosus (SLE): Blood sample , Chakravarty E Physician's Global Assessment (PGA) score 1.0 on a 0 to 3 visual analog scale. JSS Medical Research. Chaigne B et al. In one study [25], the PGA of disease activity resulted from the combination of the clinical visit, laboratory markers evaluation and the physicians knowledge of the patient disease history. Introduction Physician global assessments of disease activity (medical doctor (MD) globals) are important outcomes. Despite the need for new treatments in CLE . The Janus kinase (Jak)/signal transducer and activating protein (STAT) pathways mediate the intracellular signaling of cytokines in a wide spectrum of cellular processes. A prospective cohort study, Validity and reliability of retrospective assessment of disease activity and flare in observational cohorts of lupus patients, A novel lupus activity index accounting for glucocorticoids: SLEDAI-2K glucocorticoid index, Low disease activityirrespective of serologic status at baselineassociated with reduction of corticosteroid dose and number of flares in patients with systemic lupus erythematosus treated with belimumab: a real-life observational study, Definition and initial validation of a lupus low disease activity state (LLDAS), A framework for remission in SLE: consensus findings from a large international task force on definitions of remission in SLE (DORIS), Prolonged remission in Caucasian patients with SLE: prevalence and outcomes, 2019 update of the EULAR recommendations for the management of systemic lupus erythematosus, PRISMA Group. At a glance: Common scores used in rheumatology Kandane-Rathnayake R, Louthrenoo W, Hoi A, Luo SF, Wu YJ, Chen YH, Cho J, Lateef A, Hamijoyo L, Navarra SV, Zamora L, Sockalingam S, An Y, Li Z, Katsumata Y, Harigai M, Hao Y, Zhang Z, Kikuchi J, Takeuchi T, Basnayake BMDB, Chan M, Ng KPL, Tugnet N, Kumar S, Oon S, Goldblatt F, O'Neill S, Gibson KA, Ohkubo N, Tanaka Y, Bae SC, Lau CS, Nikpour M, Golder V, Morand EF; Asia-Pacific Lupus Collaboration. Results. et al. The index assesses separately eight organ-based systems. , Sayedbonakdar Z Laboratory Investigation Results Influence Physician's Global Supporting the face validity property, PGA was defined the gold standard in 11 studies [2, 10, 11, 21, 23, 49, 67, 76, 78, 84, 88] and in 32 it was used as the reference to which other activity scores were compared, such as the SLEDAI [4, 10, 13, 25, 27, 28, 31, 33, 35, 36, 41, 46, 47, 50, 51, 53, 62, 65, 68, 72, 73, 76, 81, 9699], BILAG [4, 27, 35, 36, 46, 65, 72, 73, 81, 98], SLAM [4, 72, 76, 99], LAI [68, 88], patient global assessment [81, 83, 84] and ECLAM [35]. Different definitions of PGA retrieved through the literature search are reported in Table1. et al. Of note, it is not trivial that we found a good convergent validity with other instruments (SLEDAI, BILAG, LAI, SLAM and ECLAM) [10, 23, 24, 26, 28, 29, 35, 54, 68, 76, 84, 99]. 2021 Apr 8;5(1):33. doi: 10.1186/s41687-021-00298-x. , Ko T 2014 Sep-Oct;10(5):309-20. doi: 10.1016/j.reuma.2014.01.012. ~SLE~. , Beresford MW The PGA was introduced in 1998 by a US Food and Drug Administration panel as the preferred tool to assess and record the severity of disease in clinical studies, and typically rates a patient's disease from 'clear' to 'severe' or 'very severe' [1, 2]. In 1988, Liang et al. European League Against Rheumatism. In 16 studies the PGA was used as a mean to assess changes in disease activity after treatment [3, 12, 22, 29, 40, 42, 43, 52, 54, 56, 57, 80, 85, 87, 95, 98, 101]. , Henriques C , Urowitz MB Help us improve CareerBuilder by providing feedback about this job: Report this job Job ID: 2281236908. Quimby KR 2022 Sep;8(2):e002395. , Saad-Magalhes C et al. , Petri M. Iaccarino L Feasibility is the ease of application of the instrument of measure in its intended setting [106]. , Hochberg M. Touma Z Mok CC Observed and articulated management issues and responses. Physician Global Assessment (PGA) is a visual analogue score (VAS) that reflects the clinician's judgment of overall Systemic Lupus Erythematosus (SLE) disease activity. The last MEDLINE search was performed on 1 July 2019. Barr SG SLE or at an SLE site, but only if the injury requires treatment by a licensed medical doctor. The SELENA-SLEDAI assesses systemic lupus erythematosus (SLE) disease activity and categorizes mild/moderate or severe flares based on changes in the SLEDAI score, the Physician's Global Assessment (PGA), medication use (prednisone, Nonsteroidal anti-inflammatory drugs, Plaquenil, major immunosuppressives), other disease activity criteria, and . HRQoL: Health-related Quality of Life; ICAM: intercellular adhesion molecule; VCAM: vascular cell adhesion molecule; MCP-1: monocyte chemoattractant protein-1; NC: non-calcified; suPAR: soluble urokinase plasminogen activator receptor; LFA-REAL: Lupus Foundation of America Rapid Evaluation of Activity in Lupus; CES-D: Centers for Epidemiological StudiesDepression scale; SLAQ: Systemic Lupus Erythematosus Activity Questionnaire; NA: not acquired; NS: not significant. Objective Physician's global assessment (PGA) of disease activity is a major determinant of therapeutic decision making. et al. This property is reported across all articles selected through this systematic review [24, 913, 21103]. All rights reserved. Assessing disease activity in rheumatic diseases such as systemic lupus erythematosus (SLE) is vital for effective treatment. , Schirmbeck LA , Allen E Cutaneous lupus erythematosus (CLE) is an autoimmune skin disease that can occur with or without systemic lupus erythematosus (SLE). The Systemic Lupus Activity Measure-revised, the Mexican Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), and a modified SLEDAI-2K are adequate instruments to measure disease activity in systemic lupus erythematosus. Thus the development of a comprehensive index for assessing disease activity still represents one of the most important challenges in SLE [7].

Who Died In The Duggar Family 2021, Sysco Driver Work Schedule, Walter Scott Whispers Wife, Articles P